> ## Documentation Index
> Fetch the complete documentation index at: https://docs.boltz.bio/llms.txt
> Use this file to discover all available pages before exploring further.
# Submitting a Prediction
> How to submit a prediction in Sandbox mode
In **Sandbox**, click **New Prediction** to get started.
After naming your prediction with an identifiable description, add polymers, small molecules and cofactors to be included in the complex.
## Adding Components
Import a .cif file or provide an RCSB PDB code to load all protein, RNA and DNA sequences, ligands and cofactors present in the file.
Import small molecules using a SMILES string, the structure drawer, or from an RCSB CCD code.
Add protein, RNA and DNA sequences individually from UniProt or FASTA strings. Modified amino acids and nucleic acids can be specified when adding a sequence.
***
## Constraints
On the **Constraints** page, add any bond, contact or pocket-contact information to guide the prediction.
Alternatively, skip this step to continue without constraints.
| Constraint Type | Description |
| :-------------- | :------------------------------------------------------------------------------------------------------- |
| **Bond** | Specify a covalent bond between atoms in the complex. Important for covalent ligands or cyclic proteins. |
| **Contact** | Specify a maximum distance (4-20 Å) between a pair of atoms as a hint to the model. |
| **Pocket** | Specify residues that a particular binder chain must be within a certain distance from. |
**Please see our dedicated Constraints documentation for full details**
***
## Affinity Prediction
The **Affinity** page lets you select a ligand to calculate binding affinity for ligand-protein interactions, or skip this step to run a structure-only prediction.
Only ligands with exactly one copy are allowed for affinity calculation.
When you're ready, click **Submit Prediction**.